Cargando…

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

INTRODUCTION: Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable candidate. METHODS: A randomized, doubl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernandez, Gerson D., Solinsky, Christine M., Mack, Wendy J., Kono, Naoko, Rodgers, Kathleen E., Wu, Chun‐Yi, Mollo, Ana R., Lopez, Claudia M., Pawluczyk, Sonia, Bauer, Gerhard, Matthews, Dawn, Shi, Yonggang, Law, Meng, Rogawski, Michael A., Schneider, Lon S., Brinton, Roberta D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744018/ https://www.ncbi.nlm.nih.gov/pubmed/33344752 http://dx.doi.org/10.1002/trc2.12107

Ejemplares similares

Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease
por: Irwin, Ronald W., et al.
Publicado: (2015)

Exploratory imaging outcomes of a phase 1b/2a clinical trial of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: Structural effects and functional connectivity outcomes
por: Raikes, Adam C., et al.
Publicado: (2022)

Allopregnanolone: Regenerative therapeutic to restore neurological health
por: Hernandez, Gerson D., et al.
Publicado: (2022)

Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders
por: Irwin, Ronald W., et al.
Publicado: (2014)

Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
por: Bruun, Donald A., et al.
Publicado: (2023)

Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease
por: Irwin, Ronald W., et al.
Publicado: (2012)

Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery
por: Zolkowska, Dorota, et al.
Publicado: (2021)

First‐in‐man allopregnanolone use in super‐refractory status epilepticus
por: Vaitkevicius, Henrikas, et al.
Publicado: (2017)

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential
por: Wang, Jun Ming, et al.
Publicado: (2008)

Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
por: Ming Wang, Jun, et al.
Publicado: (2007)

Allopregnanolone in Postpartum Depression
por: Pinna, Graziano, et al.
Publicado: (2022)

Trajectories of Allopregnanolone and Allopregnanolone to Progesterone Ratio across the Six Subphases of Menstrual Cycle
por: Hamidovic, Ajna, et al.
Publicado: (2023)

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate‐induced status epilepticus in rats
por: Dhir, Ashish, et al.
Publicado: (2020)

Allopregnanolone and neurogenesis in the nigrostriatal tract
por: Wang, Jun Ming
Publicado: (2014)

Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimer's Disease
por: Chen, Shuhua, et al.
Publicado: (2011)

Correction: Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer's Disease
Publicado: (2015)

Biosynthesis and biological action of pineal allopregnanolone
por: Tsutsui, Kazuyoshi, et al.
Publicado: (2014)

Allopregnanolone: An overview on its synthesis and effects
por: Diviccaro, Silvia, et al.
Publicado: (2021)

Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders
por: Walkery, Autumn, et al.
Publicado: (2021)

4512 Allopregnanolone Dose Finding for Status Epilepticus Treatment by Pharmacokinetic-Pharmacodynamic Modeling using Quantitative EEG in Dogs
por: Patterson, Edward “Ned”, et al.
Publicado: (2020)

Allopregnanolone and neuroinflammation: a focus on multiple sclerosis
por: Noorbakhsh, Farshid, et al.
Publicado: (2014)

Allopregnanolone in postpartum depression: Role in pathophysiology and treatment
por: Meltzer-Brody, Samantha, et al.
Publicado: (2020)

Divergent Transcriptomic Effects of Allopregnanolone in Postpartum Depression
por: Rudzinskas, Sarah A., et al.
Publicado: (2023)

Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons
por: Lu, Xinguo, et al.
Publicado: (2023)

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone
por: Poisbeau, Pierrick, et al.
Publicado: (2014)

The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms
por: Osborne, Lauren M., et al.
Publicado: (2019)

Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks
por: Drexler, Berthold, et al.
Publicado: (2020)

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells
por: Tsutsui, Kazuyoshi, et al.
Publicado: (2020)

Allopregnanolone: Metabolism, Mechanisms of Action, and Its Role in Cancer
por: Zamora-Sánchez, Carmen J., et al.
Publicado: (2022)

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone
por: Zampieri, Stefania, et al.
Publicado: (2009)

Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies
por: Desai, Amit, et al.
Publicado: (2020)

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
por: Adeosun, Samuel O., et al.
Publicado: (2012)

Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells
por: Zamora-Sánchez, Carmen J., et al.
Publicado: (2018)

Allopregnanolone alters follicular and luteal dynamics during the estrous cycle
por: Asensio, Joana Antonela, et al.
Publicado: (2018)

Allopregnanolone: A neurosteroid for managing acute and chronic pain conditions
por: Nair, Abhijit S., et al.
Publicado: (2019)

Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?
por: Pinna, Graziano
Publicado: (2020)

Overview of the Molecular Steps in Steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone
por: Liang, Jennifer J., et al.
Publicado: (2018)

The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
por: Almeida, Felipe Borges, et al.
Publicado: (2020)

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective
por: Paul, Steven M, et al.
Publicado: (2020)

Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?
por: Bortolato, Marco, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nom805ptj6hfeh4tfgpltq2fa1