Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex

Loss of hepatic fructose-1, 6-bisphosphate aldolase B (Aldob) leads to a paradoxical up-regulation of glucose metabolism to favor hepatocellular carcinogenesis (HCC), but the upstream signaling events remain poorly defined. Akt is highly activated in HCC, and targeting Akt is being explored as a pot...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xuxiao, Li, Min, Yu, Hongming, Liu, Guijun, Wang, Ningning, Yin, Chunzhao, Tu, Qiaochu, Narla, Goutham, Tao, Yongzhen, Cheng, Shuqun, Yin, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744066/
https://www.ncbi.nlm.nih.gov/pubmed/33275593
http://dx.doi.org/10.1371/journal.pbio.3000803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744066/
https://www.ncbi.nlm.nih.gov/pubmed/33275593
http://dx.doi.org/10.1371/journal.pbio.3000803

Ejemplares similares