Translation in amino-acid-poor environments is limited by tRNA(Gln) charging

An inadequate supply of amino acids leads to accumulation of uncharged tRNAs, which can bind and activate GCN2 kinase to reduce translation. Here, we show that glutamine-specific tRNAs selectively become uncharged when extracellular amino acid availability is compromised. In contrast, all other tRNA...

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Detalles Bibliográficos
Autores principales: Pavlova, Natalya N, King, Bryan, Josselsohn, Rachel H, Violante, Sara, Macera, Victoria L, Vardhana, Santosha A, Cross, Justin R, Thompson, Craig B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
https://www.ncbi.nlm.nih.gov/pubmed/33289483
http://dx.doi.org/10.7554/eLife.62307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
https://www.ncbi.nlm.nih.gov/pubmed/33289483
http://dx.doi.org/10.7554/eLife.62307

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