Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster. Among the metabolites that changed, levels of tyrosine were increased with age in long-lived...

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Detalles Bibliográficos
Autores principales: Parkhitko, Andrey A, Ramesh, Divya, Wang, Lin, Leshchiner, Dmitry, Filine, Elizabeth, Binari, Richard, Olsen, Abby L, Asara, John M, Cracan, Valentin, Rabinowitz, Joshua D, Brockmann, Axel, Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744100/
https://www.ncbi.nlm.nih.gov/pubmed/33319750
http://dx.doi.org/10.7554/eLife.58053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744100/
https://www.ncbi.nlm.nih.gov/pubmed/33319750
http://dx.doi.org/10.7554/eLife.58053

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