The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1-mutant lung cancer

In non–small cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumor suppressor STK11 encoding the kinase LKB1 result in aggressive tumors prone to metastasis but with liabilities arising from reprogrammed metabolism. We previously demonstrated perturbed nitrogen metabolism...

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Detalles Bibliográficos
Autores principales: Kim, Jiyeon, Lee, Hyun Min, Cai, Feng, Ko, Bookyung, Yang, Chendong, Lieu, Elizabeth L., Muhammad, Nefertiti, Rhyne, Shawn, Li, Kailong, Haloul, Mohamed, Gu, Wen, Faubert, Brandon, Kaushik, Akash K., Cai, Ling, Kasiri, Sahba, Marriam, Ummay, Nham, Kien, Girard, Luc, Wang, Hui, Sun, Xiankai, Kim, James, Minna, John D., Unsal-Kacmaz, Keziban, DeBerardinis, Ralph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744327/
https://www.ncbi.nlm.nih.gov/pubmed/33257855
http://dx.doi.org/10.1038/s42255-020-00316-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744327/
https://www.ncbi.nlm.nih.gov/pubmed/33257855
http://dx.doi.org/10.1038/s42255-020-00316-0

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