Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels

Hibernation is a state of extraordinary metabolic plasticity. The pathways of amino acid metabolism as they relate to nitrogen homeostasis in hibernating mammals in vivo is unknown. Here we show, using pulse isotopic tracing, evidence of increased myofibrillar (skeletal muscle) protein breakdown and...

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Detalles Bibliográficos
Autores principales: Rice, Sarah A., ten Have, Gabriella A.M., Reisz, Julie A., Gehrke, Sarah, Stefanoni, Davide, Frare, Carla, Barati, Zeinab, Coker, Robert H., D’Alessandro, Angelo, Deutz, Nicolaas E.P., Drew, Kelly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744440/
https://www.ncbi.nlm.nih.gov/pubmed/33288952
http://dx.doi.org/10.1038/s42255-020-00312-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744440/
https://www.ncbi.nlm.nih.gov/pubmed/33288952
http://dx.doi.org/10.1038/s42255-020-00312-4

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