Single cell lineage analysis reveals extensive multimodal transcriptional control during directed β-cell differentiation

The in vitro differentiation of insulin-producing β-like cells can model aspects of human pancreatic development. Here we generate 95,308 single cell transcriptomes and reconstruct a lineage tree of the entire differentiation process from hESCs to β-like cells to study temporally regulated genes dur...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Chen, Xi, Jiajia, Li, Haiyan, Cui, Jian, Gu, Anniya, Lai, Sisi, Leskov, Konstantin, Ke, Luxin, Jin, Fulai, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744443/
https://www.ncbi.nlm.nih.gov/pubmed/33257854
http://dx.doi.org/10.1038/s42255-020-00314-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744443/
https://www.ncbi.nlm.nih.gov/pubmed/33257854
http://dx.doi.org/10.1038/s42255-020-00314-2

Ejemplares similares