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Single cell lineage analysis reveals extensive multimodal transcriptional control during directed β-cell differentiation
The in vitro differentiation of insulin-producing β-like cells can model aspects of human pancreatic development. Here we generate 95,308 single cell transcriptomes and reconstruct a lineage tree of the entire differentiation process from hESCs to β-like cells to study temporally regulated genes dur...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744443/ https://www.ncbi.nlm.nih.gov/pubmed/33257854 http://dx.doi.org/10.1038/s42255-020-00314-2 |