Cargando…
Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases
Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected. Among the mechanisms that have been suggested for this enigmatic phenomenon is dosage-sensitive compensation by paralogs of causal genes. Accord...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744645/ https://www.ncbi.nlm.nih.gov/pubmed/33363699 http://dx.doi.org/10.1016/j.csbj.2020.10.030 |