Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model

The wide application of new DNA sequencing technologies is generating vast quantities of genetic variation data at unprecedented speed. Developing methodologies to decode the pathogenicity of the variants is imperatively demanding. We hypothesized that as deleterious variants may function through di...

Descripción completa

Detalles Bibliográficos
Autores principales: Tam, Benjamin, Sinha, Siddharth, Wang, San Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744649/
https://www.ncbi.nlm.nih.gov/pubmed/33363700
http://dx.doi.org/10.1016/j.csbj.2020.11.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744649/
https://www.ncbi.nlm.nih.gov/pubmed/33363700
http://dx.doi.org/10.1016/j.csbj.2020.11.041

Ejemplares similares