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Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model
The wide application of new DNA sequencing technologies is generating vast quantities of genetic variation data at unprecedented speed. Developing methodologies to decode the pathogenicity of the variants is imperatively demanding. We hypothesized that as deleterious variants may function through di...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744649/ https://www.ncbi.nlm.nih.gov/pubmed/33363700 http://dx.doi.org/10.1016/j.csbj.2020.11.041 |