Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice

The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a...

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Autores principales: Kuwentrai, Chaiyaporn, Yu, Jinming, Rong, Li, Zhang, Bao‐Zhong, Hu, Ye‐Fan, Gong, Hua‐Rui, Dou, Ying, Deng, Jian, Huang, Jian‐Dong, Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744900/
https://www.ncbi.nlm.nih.gov/pubmed/33349797
http://dx.doi.org/10.1002/btm2.10202
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author Kuwentrai, Chaiyaporn
Yu, Jinming
Rong, Li
Zhang, Bao‐Zhong
Hu, Ye‐Fan
Gong, Hua‐Rui
Dou, Ying
Deng, Jian
Huang, Jian‐Dong
Xu, Chenjie
author_facet Kuwentrai, Chaiyaporn
Yu, Jinming
Rong, Li
Zhang, Bao‐Zhong
Hu, Ye‐Fan
Gong, Hua‐Rui
Dou, Ying
Deng, Jian
Huang, Jian‐Dong
Xu, Chenjie
author_sort Kuwentrai, Chaiyaporn
collection PubMed
description The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.
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spelling pubmed-77449002020-12-17 Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice Kuwentrai, Chaiyaporn Yu, Jinming Rong, Li Zhang, Bao‐Zhong Hu, Ye‐Fan Gong, Hua‐Rui Dou, Ying Deng, Jian Huang, Jian‐Dong Xu, Chenjie Bioeng Transl Med Rapid Communication The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection. John Wiley & Sons, Inc. 2020-12-12 /pmc/articles/PMC7744900/ /pubmed/33349797 http://dx.doi.org/10.1002/btm2.10202 Text en © 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Rapid Communication
Kuwentrai, Chaiyaporn
Yu, Jinming
Rong, Li
Zhang, Bao‐Zhong
Hu, Ye‐Fan
Gong, Hua‐Rui
Dou, Ying
Deng, Jian
Huang, Jian‐Dong
Xu, Chenjie
Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title_full Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title_fullStr Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title_full_unstemmed Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title_short Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
title_sort intradermal delivery of receptor‐binding domain of sars‐cov‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744900/
https://www.ncbi.nlm.nih.gov/pubmed/33349797
http://dx.doi.org/10.1002/btm2.10202
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