Induction and repression effects on CYP and transporter protein abundance by azole mixture uptake in rat liver

Detection of mixture effects is a major challenge in current experimental and regulatory toxicology. Robust markers are needed that are easy to quantify and responsive to chemical stressors in a broad dose range. Several hepatic enzymes and proteins related to drug metabolism like cytochrome-P-450 (...

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Detalles Bibliográficos
Autores principales: Hammer, Helen, Schmidt, Flavia, Heise, Tanja, Knebel, Constanze, Dabrowski, Alexander, Planatscher, Hannes, Kneuer, Carsten, Marx-Stoelting, Philip, Pötz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744963/
https://www.ncbi.nlm.nih.gov/pubmed/33343269
http://dx.doi.org/10.17179/excli2020-2311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744963/
https://www.ncbi.nlm.nih.gov/pubmed/33343269
http://dx.doi.org/10.17179/excli2020-2311

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