NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

Tyrosine kinase domains dynamically fluctuate between two main structural forms that are referred to as type I (DFG-in) or type II (DFG-out) conformations. Comprehensive data comparing type I and type II inhibitors are currently lacking for NTRK fusion-driven cancers. Here we used a type II NTRK inh...

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Detalles Bibliográficos
Autores principales: Somwar, Romel, Hofmann, Nicolle E., Smith, Bryan, Odintsov, Igor, Vojnic, Morana, Linkov, Irina, Tam, Ashley, Khodos, Inna, Mattar, Marissa S., de Stanchina, Elisa, Flynn, Daniel, Ladanyi, Marc, Drilon, Alexander, Shinde, Ujwal, Davare, Monika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745027/
https://www.ncbi.nlm.nih.gov/pubmed/33328556
http://dx.doi.org/10.1038/s42003-020-01508-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745027/
https://www.ncbi.nlm.nih.gov/pubmed/33328556
http://dx.doi.org/10.1038/s42003-020-01508-w

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