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K(ATP) Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema
Pharmacological openers of ATP-sensitive potassium (K(ATP)) channels are effective antihypertensive agents, but off-target effects, including severe peripheral edema, limit their clinical usefulness. It is presumed that the arterial dilation induced by K(ATP) channel openers (KCOs) increases capilla...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745085/ https://www.ncbi.nlm.nih.gov/pubmed/33100270 http://dx.doi.org/10.1124/jpet.120.000121 |