Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design

[Image: see text] Fragment screening is frequently used for hit identification. However, there was no report starting from a small fragment for the development of an anaplastic lymphoma kinase (ALK) inhibitor, despite the number of ALK inhibitors reported. We began our research with the fragment hit...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujimori, Ikuo, Wakabayashi, Takeshi, Murakami, Morio, Okabe, Atsutoshi, Ishii, Tsuyoshi, McGrath, Aaron, Zou, Hua, Saikatendu, Kumar Singh, Imoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745413/
https://www.ncbi.nlm.nih.gov/pubmed/33344853
http://dx.doi.org/10.1021/acsomega.0c04900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745413/
https://www.ncbi.nlm.nih.gov/pubmed/33344853
http://dx.doi.org/10.1021/acsomega.0c04900

Ejemplares similares