The Role of Orthosteric Building Blocks of Bitopic Ligands for Muscarinic M1 Receptors

[Image: see text] The muscarinic M(1) acetylcholine receptor is an important drug target for the treatment of various neurological disorders. Designing M(1) receptor-selective drugs has proven challenging, mainly due to the high conservation of the acetylcholine binding site among muscarinic recepto...

Descripción completa

Detalles Bibliográficos
Autores principales: Volpato, Daniela, Kauk, Michael, Messerer, Regina, Bermudez, Marcel, Wolber, Gerhard, Bock, Andreas, Hoffmann, Carsten, Holzgrabe, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745449/
https://www.ncbi.nlm.nih.gov/pubmed/33344823
http://dx.doi.org/10.1021/acsomega.0c04220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745449/
https://www.ncbi.nlm.nih.gov/pubmed/33344823
http://dx.doi.org/10.1021/acsomega.0c04220

Ejemplares similares