Suprachoroidally Delivered DNA Nanoparticles Transfect Retina and Retinal Pigment Epithelium/Choroid in Rabbits

PURPOSE: This study evaluated ocular tolerability and transfectability of nonviral DNA nanoparticles (DNPs) after microneedle-based suprachoroidal (SC) administration, in comparison to subretinal (SR) administration. METHODS: The DNPs consisted of a single copy of plasmid DNA with a polyubiquitin C/...

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Detalles Bibliográficos
Autores principales: Kansara, Viral S., Cooper, Mark, Sesenoglu-Laird, Ozge, Muya, Leroy, Moen, Robert, Ciulla, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745627/
https://www.ncbi.nlm.nih.gov/pubmed/33364076
http://dx.doi.org/10.1167/tvst.9.13.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745627/
https://www.ncbi.nlm.nih.gov/pubmed/33364076
http://dx.doi.org/10.1167/tvst.9.13.21

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