Transcriptomic and proteomic intra-tumor heterogeneity of colorectal cancer varies depending on tumor location within the colorectum

BACKGROUND: Intra-tumor heterogeneity (ITH) of colorectal cancer (CRC) complicates molecular tumor classification, such as transcriptional subtyping. Differences in cellular states, biopsy cell composition, and tumor microenvironment may all lead to ITH. Here we analyze ITH at the transcriptomic and...

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Detalles Bibliográficos
Autores principales: Árnadóttir, Sigrid Salling, Mattesen, Trine Block, Vang, Søren, Madsen, Mogens Rørbæk, Madsen, Anders Husted, Birkbak, Nicolai Juul, Bramsen, Jesper Bertram, Andersen, Claus Lindbjerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746197/
https://www.ncbi.nlm.nih.gov/pubmed/33332369
http://dx.doi.org/10.1371/journal.pone.0241148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746197/
https://www.ncbi.nlm.nih.gov/pubmed/33332369
http://dx.doi.org/10.1371/journal.pone.0241148

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