A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

High-throughput testing of drugs across molecular-characterised cell lines can identify candidate treatments and discover biomarkers. However, the cells’ response to a drug is typically quantified by a summary statistic from a best-fit dose-response curve, whilst neglecting the uncertainty of the cu...

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Detalles Bibliográficos
Autores principales: Wang, Dennis, Hensman, James, Kutkaite, Ginte, Toh, Tzen S, Galhoz, Ana, Dry, Jonathan R, Saez-Rodriguez, Julio, Garnett, Mathew J, Menden, Michael P, Dondelinger, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746236/
https://www.ncbi.nlm.nih.gov/pubmed/33274713
http://dx.doi.org/10.7554/eLife.60352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746236/
https://www.ncbi.nlm.nih.gov/pubmed/33274713
http://dx.doi.org/10.7554/eLife.60352

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