Cargando…

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019 (COVID-19), a global healthcare and economic catastrophe. Understanding of the host immune response to SARS-CoV-2 is still in its infancy. A 382-nt deletion strain lacking ORF8 (Δ382 herein) was isolated in Singapore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gamage, Akshamal M., Tan, Kai Sen, Chan, Wharton O. Y., Liu, Jing, Tan, Chee Wah, Ong, Yew Kwang, Thong, Mark, Andiappan, Anand K., Anderson, Danielle E., Wang, De Yun, Wang, Lin-Fa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746279/ https://www.ncbi.nlm.nih.gov/pubmed/33284849 http://dx.doi.org/10.1371/journal.ppat.1009130

Ejemplares similares

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2
por: Su, Yvonne C. F., et al.
Publicado: (2020)

Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response
por: Gamage, Akshamal M., et al.
Publicado: (2022)

Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor
por: Tan, Chee Wah, et al.
Publicado: (2023)

Decoding bat immunity: the need for a coordinated research approach
por: Wang, Lin-Fa, et al.
Publicado: (2021)

ORF8 ∆382 Mutation: A Possible Viral Prognostic Biomarker for the Severity of the COVID-19
por: Tabibzadeh, Alireza, et al.
Publicado: (2021)

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021
por: Mazur-Panasiuk, Natalia, et al.
Publicado: (2021)

Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host–pathogen interactions in the bat airway epithelium
por: Chan, Louisa L.Y., et al.
Publicado: (2022)

Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium
por: Chen, Qianmin, et al.
Publicado: (2020)

RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications
por: Tan, Kai Sen, et al.
Publicado: (2019)

Séminaire Bourbaki : exposés 382–399
por: Collective
Publicado: (1972)

The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation
por: Fu, Xiaoyu, et al.
Publicado: (2012)

Retraction: The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation
por: Fu, Xiaoyu, et al.
Publicado: (2013)

382 An Unusual Reaction to Intravenous Iron Sucrose
por: Balduzzi, Michael, et al.
Publicado: (2012)

Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment
por: Hong, Haiyu, et al.
Publicado: (2021)

An Integrated Analysis of Radial Spoke Head and Outer Dynein Arm Protein Defects and Ciliogenesis Abnormality in Nasal Polyps
por: Zi, Xiao-xue, et al.
Publicado: (2019)

MD 382: Beam Transfer Function and diffusion mechanisms
por: Tambasco, Claudia, et al.
Publicado: (2016)

MON-382 An Adrenal Incidentaloma: The Dilemma over Dopamine
por: Yedla, Niharika, et al.
Publicado: (2019)

Correction to Lancet Oncol 2022; 23: 382–92
Publicado: (2022)

Genetic distance in the whole-genome perspective on Listeria monocytogenes strains F2-382 and NIHS-28 that show similar subtyping results
por: Kyoui, Daisuke, et al.
Publicado: (2014)

Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection
por: Chen, Zhuang Gui, et al.
Publicado: (2019)

Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab
por: Keng, Choong-Tat, et al.
Publicado: (2009)

Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps
por: Peng, Yang, et al.
Publicado: (2018)

SUN-382 Craniopharyngioma Patients Are at Risk of Impaired Bone Health
por: van Santen, Selveta Sanne
Publicado: (2020)

Epidemiological Characteristics of 69,382 COVID-19 Patients in Oman
por: Al Awaidy, Salah T., et al.
Publicado: (2021)

Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2
por: Anderson, Danielle E., et al.
Publicado: (2020)

Lack of Processing of the Expressed ORF1 Gene Product of Hepatitis E Virus
por: Suppiah, Suganthi, et al.
Publicado: (2011)

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor
por: Yousefi, Meisam, et al.
Publicado: (2023)

Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
por: Tang, Zhizhong, et al.
Publicado: (2023)

Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis
por: Ho, Wan Yun, et al.
Publicado: (2020)

Use of a point-of-care test to rapidly assess levels of SARS-CoV-2 nasal neutralising antibodies in vaccinees and breakthrough infected individuals
por: Tan, Chee Wah, et al.
Publicado: (2023)

MED15/382: Co-operative Interface in Medical Education on the WWW
por: Courtin, C, et al.
Publicado: (1999)

miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma
por: Xu, Meng, et al.
Publicado: (2014)

MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer
por: Yao, Hui, et al.
Publicado: (2019)

382. Difference in Pathogens Between Hip and Knee Prosthetic Joint Infection
por: Henry, Michael, et al.
Publicado: (2019)

382 Strategies for commercializing non-patentable innovations developed at CTSA hubs
por: Quanbeck, Andrew, et al.
Publicado: (2022)

April 2021 (vol. 224, no. 4, page 382.e2)
Publicado: (2023)

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2
por: Zinzula, Luca
Publicado: (2021)

Similarity-based gene detection: using COGs to find evolutionarily-conserved ORFs
por: Powell, Bradford C, et al.
Publicado: (2006)

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection
por: Fong, Siew-Wai, et al.
Publicado: (2021)

miR-382 targeting PTEN-Akt axis promotes liver regeneration
por: Bei, Yihua, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0qnnqmtrv2iia8i6k4m37j0lij