Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage

DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonucleases to generate targeted breaks. Here, we describe a...

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Detalles Bibliográficos
Autores principales: House, Nealia C. M., Parasuram, Ramya, Layer, Jacob V., Price, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746297/
https://www.ncbi.nlm.nih.gov/pubmed/33332350
http://dx.doi.org/10.1371/journal.pone.0237759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746297/
https://www.ncbi.nlm.nih.gov/pubmed/33332350
http://dx.doi.org/10.1371/journal.pone.0237759

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