In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma

Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NN...

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Detalles Bibliográficos
Autores principales: Zhou, Hui, Lei, Meng, Wang, Wang, Guo, Mengjie, Wang, Jia, Zhang, Haoyang, Qiao, Li, Feng, Huayun, Liu, Zhaogang, Chen, Lijuan, Hou, Jianhao, Wang, Xueyuan, Gu, Chenxi, Zhao, Bo, Izumchenko, Evgeny, Yang, Ye, Zhu, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746380/
https://www.ncbi.nlm.nih.gov/pubmed/33203800
http://dx.doi.org/10.18632/aging.104023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746380/
https://www.ncbi.nlm.nih.gov/pubmed/33203800
http://dx.doi.org/10.18632/aging.104023

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