Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission

The amyotrophic lateral sclerosis (ALS) neurodegenerative disorder has been associated with multiple genetic lesions, including mutations in the gene for fused in sarcoma (FUS), a nuclear-localized RNA/DNA-binding protein. Neuronal expression of the pathological form of FUS proteins in Caenorhabditi...

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Detalles Bibliográficos
Autores principales: Markert, Sebastian M., Skoruppa, Michael, Yu, Bin, Mulcahy, Ben, Zhen, Mei, Gao, Shangbang, Sendtner, Michael, Stigloher, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746668/
https://www.ncbi.nlm.nih.gov/pubmed/33148607
http://dx.doi.org/10.1242/bio.055129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746668/
https://www.ncbi.nlm.nih.gov/pubmed/33148607
http://dx.doi.org/10.1242/bio.055129

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