Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Huntington’s disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT i...

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Detalles Bibliográficos
Autores principales: Fodale, Valentina, Pintauro, Roberta, Daldin, Manuel, Altobelli, Roberta, Spiezia, Maria Carolina, Bisbocci, Monica, Macdonald, Douglas, Bresciani, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746729/
https://www.ncbi.nlm.nih.gov/pubmed/33335120
http://dx.doi.org/10.1038/s41598-020-78790-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746729/
https://www.ncbi.nlm.nih.gov/pubmed/33335120
http://dx.doi.org/10.1038/s41598-020-78790-5

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