Aging-associated distinctive DNA methylation changes of LINE-1 retrotransposons in pure cell-free DNA from human blood

LINE-1 hypomethylation of cell-free DNA has been described as an epigenetic biomarker of human aging. However, in the past, insufficient differentiation between cellular and cell-free DNA may have confounded analyses of genome-wide methylation levels in aging cells. Here we present a new methodologi...

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Detalles Bibliográficos
Autores principales: Mahmood, Wardah, Erichsen, Lars, Ott, Pauline, Schulz, Wolfgang A., Fischer, Johannes C., Arauzo-Bravo, Marcos J., Bendhack, Marcelo L., Hassan, Mohamed, Santourlidis, Simeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746734/
https://www.ncbi.nlm.nih.gov/pubmed/33335196
http://dx.doi.org/10.1038/s41598-020-79126-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746734/
https://www.ncbi.nlm.nih.gov/pubmed/33335196
http://dx.doi.org/10.1038/s41598-020-79126-z

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