Multiple random phosphorylations in clock proteins provide long delays and switches

Theory predicts that self-sustained oscillations require robust delays and nonlinearities (ultrasensitivity). Delayed negative feedback loops with switch-like inhibition of transcription constitute the core of eukaryotic circadian clocks. The kinetics of core clock proteins such as PER2 in mammals a...

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Detalles Bibliográficos
Autores principales: Upadhyay, Abhishek, Marzoll, Daniela, Diernfellner, Axel, Brunner, Michael, Herzel, Hanspeter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746754/
https://www.ncbi.nlm.nih.gov/pubmed/33335302
http://dx.doi.org/10.1038/s41598-020-79277-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746754/
https://www.ncbi.nlm.nih.gov/pubmed/33335302
http://dx.doi.org/10.1038/s41598-020-79277-z

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