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Multiple random phosphorylations in clock proteins provide long delays and switches
Theory predicts that self-sustained oscillations require robust delays and nonlinearities (ultrasensitivity). Delayed negative feedback loops with switch-like inhibition of transcription constitute the core of eukaryotic circadian clocks. The kinetics of core clock proteins such as PER2 in mammals a...
Autores principales: | Upadhyay, Abhishek, Marzoll, Daniela, Diernfellner, Axel, Brunner, Michael, Herzel, Hanspeter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746754/ https://www.ncbi.nlm.nih.gov/pubmed/33335302 http://dx.doi.org/10.1038/s41598-020-79277-z |
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