Lactic Acidosis Interferes With Toxicity of Perifosine to Colorectal Cancer Spheroids: Multimodal Imaging Analysis

Colorectal cancer (CRC) is a disease with constantly increasing incidence and high mortality. The treatment efficacy could be curtailed by drug resistance resulting from poor drug penetration into tumor tissue and the tumor-specific microenvironment, such as hypoxia and acidosis. Furthermore, CRC tu...

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Detalles Bibliográficos
Autores principales: Pavlatovská, Barbora, Machálková, Markéta, Brisudová, Petra, Pruška, Adam, Štěpka, Karel, Michálek, Jan, Nečasová, Tereza, Beneš, Petr, Šmarda, Jan, Preisler, Jan, Kozubek, Michal, Navrátilová, Jarmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746961/
https://www.ncbi.nlm.nih.gov/pubmed/33344237
http://dx.doi.org/10.3389/fonc.2020.581365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746961/
https://www.ncbi.nlm.nih.gov/pubmed/33344237
http://dx.doi.org/10.3389/fonc.2020.581365

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