Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

[Image: see text] Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets. To enhance brain distribution, amyloid-β (Aβ) antibodies were fused to a transferrin recept...

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Detalles Bibliográficos
Autores principales: Syvänen, Stina, Fang, Xiaotian T, Faresjö, Rebecca, Rokka, Johanna, Lannfelt, Lars, Olberg, Dag E, Eriksson, Jonas, Sehlin, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747219/
https://www.ncbi.nlm.nih.gov/pubmed/33236886
http://dx.doi.org/10.1021/acschemneuro.0c00652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747219/
https://www.ncbi.nlm.nih.gov/pubmed/33236886
http://dx.doi.org/10.1021/acschemneuro.0c00652

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