Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells

Chemotherapy for high-grade astrocytic tumors is mainly based on the use of temozolomide (TMZ), whose efficacy is limited by resistance mechanisms. Despite many investigations pointing to O6-methylguanine-DNA-methyltransferase (MGMT) as being responsible for tumor chemo-resistance, its expression do...

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Detalles Bibliográficos
Autores principales: Serrano-Heras, Gemma, Castro-Robles, Beatriz, Romero-Sánchez, Carlos M., Carrión, Blanca, Barbella-Aponte, Rosa, Sandoval, Hernán, Segura, Tomás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747563/
https://www.ncbi.nlm.nih.gov/pubmed/33335215
http://dx.doi.org/10.1038/s41598-020-78868-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747563/
https://www.ncbi.nlm.nih.gov/pubmed/33335215
http://dx.doi.org/10.1038/s41598-020-78868-0

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