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Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells
Chemotherapy for high-grade astrocytic tumors is mainly based on the use of temozolomide (TMZ), whose efficacy is limited by resistance mechanisms. Despite many investigations pointing to O6-methylguanine-DNA-methyltransferase (MGMT) as being responsible for tumor chemo-resistance, its expression do...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747563/ https://www.ncbi.nlm.nih.gov/pubmed/33335215 http://dx.doi.org/10.1038/s41598-020-78868-0 |