MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

The efficacy of aminolevulinic acid (5-ALA)-based photodynamic diagnosis (5-ALA-PDD) and photodynamic therapy (5-ALA-PDT) is dependent on 5-ALA-induced cancer-specific accumulation of protoporphyrin IX (PpIX). We previously reported that inhibition of oncogenic Ras/MEK increases PpIX accumulation in...

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Detalles Bibliográficos
Autores principales: Chelakkot, Vipin Shankar, Liu, Kaiwen, Yoshioka, Ema, Saha, Shaykat, Xu, Danyang, Licursi, Maria, Dorward, Ann, Hirasawa, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747616/
https://www.ncbi.nlm.nih.gov/pubmed/33335181
http://dx.doi.org/10.1038/s41598-020-79144-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747616/
https://www.ncbi.nlm.nih.gov/pubmed/33335181
http://dx.doi.org/10.1038/s41598-020-79144-x

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