Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects. Here, we investigate how chirality affects the activity and mechanism of action of RJW100, a racemic agonist of the nuclear receptors liver rece...

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Detalles Bibliográficos
Autores principales: Mays, Suzanne G., Stec, Józef, Liu, Xu, D’Agostino, Emma H., Whitby, Richard J., Ortlund, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747700/
https://www.ncbi.nlm.nih.gov/pubmed/33335203
http://dx.doi.org/10.1038/s41598-020-79251-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747700/
https://www.ncbi.nlm.nih.gov/pubmed/33335203
http://dx.doi.org/10.1038/s41598-020-79251-9

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