Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Br...

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Autores principales: de Oliveira, Saulo Gomes, de Souza, Ilana Brito Ferraz, Constantino, Taynan da Silva, Silva, Paula Carolina Valença, de Lima, Elker Lene Santos, Muniz, Maria Tereza Cartaxo, Domingues, Ana Lúcia Coutinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
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Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747812/
https://www.ncbi.nlm.nih.gov/pubmed/33338108
http://dx.doi.org/10.1590/0037-8682-0145-2020
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author de Oliveira, Saulo Gomes
de Souza, Ilana Brito Ferraz
Constantino, Taynan da Silva
Silva, Paula Carolina Valença
de Lima, Elker Lene Santos
Muniz, Maria Tereza Cartaxo
Domingues, Ana Lúcia Coutinho
author_facet de Oliveira, Saulo Gomes
de Souza, Ilana Brito Ferraz
Constantino, Taynan da Silva
Silva, Paula Carolina Valença
de Lima, Elker Lene Santos
Muniz, Maria Tereza Cartaxo
Domingues, Ana Lúcia Coutinho
author_sort de Oliveira, Saulo Gomes
collection PubMed
description INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
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spelling pubmed-77478122020-12-22 Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment de Oliveira, Saulo Gomes de Souza, Ilana Brito Ferraz Constantino, Taynan da Silva Silva, Paula Carolina Valença de Lima, Elker Lene Santos Muniz, Maria Tereza Cartaxo Domingues, Ana Lúcia Coutinho Rev Soc Bras Med Trop Short Communication INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population. Sociedade Brasileira de Medicina Tropical - SBMT 2020-12-21 /pmc/articles/PMC7747812/ /pubmed/33338108 http://dx.doi.org/10.1590/0037-8682-0145-2020 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
de Oliveira, Saulo Gomes
de Souza, Ilana Brito Ferraz
Constantino, Taynan da Silva
Silva, Paula Carolina Valença
de Lima, Elker Lene Santos
Muniz, Maria Tereza Cartaxo
Domingues, Ana Lúcia Coutinho
Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title_full Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title_fullStr Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title_full_unstemmed Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title_short Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
title_sort association of the polymorphism exon 1 (a/o) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747812/
https://www.ncbi.nlm.nih.gov/pubmed/33338108
http://dx.doi.org/10.1590/0037-8682-0145-2020
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