Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Bastard, Paul, Bolze, Alexandre, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Cobat, Aurélie, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Casanova, Jean-Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410/
https://www.ncbi.nlm.nih.gov/pubmed/33363283
http://dx.doi.org/10.1016/j.medj.2020.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410/
https://www.ncbi.nlm.nih.gov/pubmed/33363283
http://dx.doi.org/10.1016/j.medj.2020.12.001

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