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Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation
The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410/ https://www.ncbi.nlm.nih.gov/pubmed/33363283 http://dx.doi.org/10.1016/j.medj.2020.12.001 |
| _version_ | 1783625105247567872 |
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| author | Zhang, Qian Bastard, Paul Bolze, Alexandre Jouanguy, Emmanuelle Zhang, Shen-Ying Cobat, Aurélie Notarangelo, Luigi D. Su, Helen C. Abel, Laurent Casanova, Jean-Laurent |
| author_facet | Zhang, Qian Bastard, Paul Bolze, Alexandre Jouanguy, Emmanuelle Zhang, Shen-Ying Cobat, Aurélie Notarangelo, Luigi D. Su, Helen C. Abel, Laurent Casanova, Jean-Laurent |
| author_sort | Zhang, Qian |
| collection | PubMed |
| description | The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. |
| format | Online Article Text |
| id | pubmed-7748410 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77484102020-12-21 Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation Zhang, Qian Bastard, Paul Bolze, Alexandre Jouanguy, Emmanuelle Zhang, Shen-Ying Cobat, Aurélie Notarangelo, Luigi D. Su, Helen C. Abel, Laurent Casanova, Jean-Laurent Med (N Y) Commentary The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. Elsevier Inc. 2020-12-18 2020-12-18 /pmc/articles/PMC7748410/ /pubmed/33363283 http://dx.doi.org/10.1016/j.medj.2020.12.001 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Commentary Zhang, Qian Bastard, Paul Bolze, Alexandre Jouanguy, Emmanuelle Zhang, Shen-Ying Cobat, Aurélie Notarangelo, Luigi D. Su, Helen C. Abel, Laurent Casanova, Jean-Laurent Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title | Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title_full | Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title_fullStr | Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title_full_unstemmed | Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title_short | Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation |
| title_sort | life-threatening covid-19: defective interferons unleash excessive inflammation |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410/ https://www.ncbi.nlm.nih.gov/pubmed/33363283 http://dx.doi.org/10.1016/j.medj.2020.12.001 |
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