Cargando…

Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Qian, Bastard, Paul, Bolze, Alexandre, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Cobat, Aurélie, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Casanova, Jean-Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748410/ https://www.ncbi.nlm.nih.gov/pubmed/33363283 http://dx.doi.org/10.1016/j.medj.2020.12.001

Ejemplares similares

Autoantibodies neutralizing type I interferons in 20% of COVID-19 deaths in a French hospital
por: Chauvineau-Grenier, Angélique, et al.
Publicado: (2021)

Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital
por: Chauvineau-Grenier, Angélique, et al.
Publicado: (2022)

Type I interferons and SARS-CoV-2: from cells to organisms
por: Bastard, Paul, et al.
Publicado: (2022)

In memoriam: Stephen J Seligman, MD: Adverse reactions to the yellow fever vaccine: from epidemiological risk factors to causes and mechanisms
por: Casanova, Jean-Laurent, et al.
Publicado: (2022)

Auto-anticorps anti-interférons de type I et COVID-19 sévère
por: Bastard, Paul, et al.
Publicado: (2021)

Controlling for human population stratification in rare variant association studies
por: Bouaziz, Matthieu, et al.
Publicado: (2021)

The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?
por: Casanova, Jean-Laurent, et al.
Publicado: (2020)

Silverlight unleashed
por: Bugnion, Laurent
Publicado: (2009)

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy
por: Fava, Vinicius M., et al.
Publicado: (2016)

Silverlight 4 unleashed
por: Bugnion, Laurent
Publicado: (2011)

No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients
por: Philippot, Quentin, et al.
Publicado: (2023)

Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia
por: Philippot, Quentin, et al.
Publicado: (2023)

Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8
por: Jackson, Carolyn C., et al.
Publicado: (2015)

Plasma Exchange to Rescue Patients with Autoantibodies Against Type I Interferons and Life-Threatening COVID-19 Pneumonia
por: de Prost, Nicolas, et al.
Publicado: (2021)

Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies
por: Casanova, Jean-Laurent, et al.
Publicado: (2014)

Worldwide vaccine inequality threatens to unleash the next COVID-19 variant
por: Oehler, Richard L., et al.
Publicado: (2022)

Distinct antibody repertoires against endemic human coronaviruses in children and adults
por: Khan, Taushif, et al.
Publicado: (2021)

Inherited IL-18BP deficiency in human fulminant viral hepatitis
por: Belkaya, Serkan, et al.
Publicado: (2019)

Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations
por: Jabot-Hanin, Fabienne, et al.
Publicado: (2016)

Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing
por: About, Frédégonde, et al.
Publicado: (2019)

Low Lymphocytes and IFN-Neutralizing Autoantibodies as Biomarkers of COVID-19 Mortality
por: Troya, Jesús, et al.
Publicado: (2022)

Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients
por: Koning, Rutger, et al.
Publicado: (2021)

Interferon-β Therapy in a Patient with Incontinentia Pigmenti and Autoantibodies against Type I IFNs Infected with SARS-CoV-2
por: Bastard, Paul, et al.
Publicado: (2021)

Detection of homozygous and hemizygous complete or partial exon deletions by whole-exome sequencing
por: Bigio, Benedetta, et al.
Publicado: (2021)

Autoantibodies against type I IFNs in patients with life-threatening COVID-19
por: Bastard, Paul, et al.
Publicado: (2020)

DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria
por: Killy, Barbara, et al.
Publicado: (2021)

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
por: Hernandez, Nicholas, et al.
Publicado: (2018)

Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs
por: Casanova, Jean-Laurent, et al.
Publicado: (2023)

Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β
por: Vinh, Donald C., et al.
Publicado: (2021)

Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma
por: Vazquez, Sara E., et al.
Publicado: (2021)

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
por: Salvagno, Camilla, et al.
Publicado: (2019)

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
por: Smith, Nikaïa, et al.
Publicado: (2022)

Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
por: Byun, Minji, et al.
Publicado: (2010)

Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients
por: Goncalves, David, et al.
Publicado: (2021)

Ubuntu unleashed
por: Helmke, Matthew, et al.
Publicado: (2019)

Ubuntu unleashed
por: Helmke, Matthew, et al.
Publicado: (2015)

Ubuntu unleashed
por: Helmke, Matthew, et al.
Publicado: (2016)

Django unleashed
por: Pinkham, Andrew
Publicado: (2016)

XAML unleashed
por: Nathan, Adam
Publicado: (2015)

Ubuntu unleashed
por: Helmke, Matthew, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g5vu3np5vanpkqsv9cnqgag31o