Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to accumulation of TDP-43 in the cytoplasm. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Jeong Hyang, Chung, Chang Geon, Park, Sung Soon, Lee, Davin, Kim, Kyung Min, Jeong, Yeonjin, Kim, Eun Seon, Cho, Jae Ho, Jeon, Yu-Mi, Shen, C-K James, Kim, Hyung-Jun, Hwang, Daehee, Lee, Sung Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748415/
https://www.ncbi.nlm.nih.gov/pubmed/33305734
http://dx.doi.org/10.7554/eLife.60132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748415/
https://www.ncbi.nlm.nih.gov/pubmed/33305734
http://dx.doi.org/10.7554/eLife.60132

Ejemplares similares