Cargando…

Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to accumulation of TDP-43 in the cytoplasm. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jeong Hyang, Chung, Chang Geon, Park, Sung Soon, Lee, Davin, Kim, Kyung Min, Jeong, Yeonjin, Kim, Eun Seon, Cho, Jae Ho, Jeon, Yu-Mi, Shen, C-K James, Kim, Hyung-Jun, Hwang, Daehee, Lee, Sung Bae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748415/ https://www.ncbi.nlm.nih.gov/pubmed/33305734 http://dx.doi.org/10.7554/eLife.60132

Ejemplares similares

CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons
por: Cho, Jae Ho, et al.
Publicado: (2022)

Recognition of the TDP-43 nuclear localization signal by importin α1/β
por: Doll, Steven G., et al.
Publicado: (2022)

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43
por: White, Anthony, et al.
Publicado: (2013)

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy
por: Clippinger, Amy K., et al.
Publicado: (2013)

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
por: Yin, Peng, et al.
Publicado: (2019)

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation
por: Walker, Adam K., et al.
Publicado: (2013)

Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons
por: van Eersel, Janet, et al.
Publicado: (2011)

Cytoplasmic TDP-43 is involved in cell fate during stress recovery
por: Lee, Youn-Bok, et al.
Publicado: (2021)

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
por: Woo, Jung-A. A., et al.
Publicado: (2017)

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients
por: Rubio, Miguel A., et al.
Publicado: (2022)

Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death
por: Candia, Robert F., et al.
Publicado: (2022)

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
por: Lee, Saebom, et al.
Publicado: (2022)

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
por: Zhang, Qiang, et al.
Publicado: (2022)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
por: Shenouda, Marc, et al.
Publicado: (2022)

FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus
por: Lee, Sun Hee, et al.
Publicado: (2014)

Assembly and Folding Properties of Cytosolic IgG Intrabodies
por: Seo, Youngsil, et al.
Publicado: (2020)

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
por: Fernandes, Nikita, et al.
Publicado: (2020)

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
por: Svahn, Adam J., et al.
Publicado: (2018)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations
por: Jeon, Gye Sun, et al.
Publicado: (2018)

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death
por: Foster, A. D., et al.
Publicado: (2021)

C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons
por: Kim, Eun Seon, et al.
Publicado: (2021)

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
por: Uchida, Azusa, et al.
Publicado: (2012)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
por: Amlie-Wolf, Alexandre, et al.
Publicado: (2015)

Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells
por: Picher-Martel, Vincent, et al.
Publicado: (2015)

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
por: Kim, Jae-Hong, et al.
Publicado: (2021)

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
por: Chang, Michael C., et al.
Publicado: (2017)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
por: Lee, Shinrye, et al.
Publicado: (2020)

Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases
por: Chung, Chang Geon, et al.
Publicado: (2020)

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients
por: Paré, Bastien, et al.
Publicado: (2015)

Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy
por: Matsukawa, Koji, et al.
Publicado: (2021)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity
por: Crippa, Valeria, et al.
Publicado: (2016)

Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43
por: Lo Piccolo, Luca, et al.
Publicado: (2018)

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis
por: Paez-Colasante, Ximena, et al.
Publicado: (2020)

Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis
por: Yabata, Hiroyuki, et al.
Publicado: (2023)

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA
por: Saldi, Tassa K, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qcs5qg187eaca6m5lgkt0mn354