The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that these events do not involve changes in Rab protein expressi...

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Detalles Bibliográficos
Autores principales: Rivas, Solange, Silva, Patricio, Reyes, Montserrat, Sepúlveda, Hugo, Solano, Luis, Acuña, Juan, Guerrero, Marisol, Varas-Godoy, Manuel, Quest, Andrew F. G., Montecino, Martín, Torres, Vicente A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749157/
https://www.ncbi.nlm.nih.gov/pubmed/33339852
http://dx.doi.org/10.1038/s41598-020-79270-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749157/
https://www.ncbi.nlm.nih.gov/pubmed/33339852
http://dx.doi.org/10.1038/s41598-020-79270-6

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