Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

A current challenge to produce effective therapeutics is to accurately determine the location of the ligand-biding site and to characterize its properties. So far, the mechanisms underlying the functional activation of cell surface receptors by ligands with a complex binding mechanism remain poorly...

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Detalles Bibliográficos
Autores principales: Dumitru, Andra C., Deepak, R. N. V. Krishna, Liu, Heng, Koehler, Melanie, Zhang, Cheng, Fan, Hao, Alsteens, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749166/
https://www.ncbi.nlm.nih.gov/pubmed/33339958
http://dx.doi.org/10.1038/s42003-020-01518-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749166/
https://www.ncbi.nlm.nih.gov/pubmed/33339958
http://dx.doi.org/10.1038/s42003-020-01518-8

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