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Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
A current challenge to produce effective therapeutics is to accurately determine the location of the ligand-biding site and to characterize its properties. So far, the mechanisms underlying the functional activation of cell surface receptors by ligands with a complex binding mechanism remain poorly...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749166/ https://www.ncbi.nlm.nih.gov/pubmed/33339958 http://dx.doi.org/10.1038/s42003-020-01518-8 |