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Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in No...

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Autores principales: Nielsen, Jonas B., Rom, Oren, Surakka, Ida, Graham, Sarah E., Zhou, Wei, Roychowdhury, Tanmoy, Fritsche, Lars G., Gagliano Taliun, Sarah A., Sidore, Carlo, Liu, Yuhao, Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Overton, William, Zhao, Ying, Chen, Jin, Zhang, He, Hornsby, Whitney E., Acheampong, Akua, Grooms, Austen, Schaefer, Amanda, Zajac, Gregory J. M., Villacorta, Luis, Zhang, Jifeng, Brumpton, Ben, Løset, Mari, Rai, Vivek, Lundegaard, Pia R., Olesen, Morten S., Taylor, Kent D., Palmer, Nicholette D., Chen, Yii-Der, Choi, Seung H., Lubitz, Steven A., Ellinor, Patrick T., Barnes, Kathleen C., Daya, Michelle, Rafaels, Nicholas, Weiss, Scott T., Lasky-Su, Jessica, Tracy, Russell P., Vasan, Ramachandran S., Cupples, L. Adrienne, Mathias, Rasika A., Yanek, Lisa R., Becker, Lewis C., Peyser, Patricia A., Bielak, Lawrence F., Smith, Jennifer A., Aslibekyan, Stella, Hidalgo, Bertha A., Arnett, Donna K., Irvin, Marguerite R., Wilson, James G., Musani, Solomon K., Correa, Adolfo, Rich, Stephen S., Guo, Xiuqing, Rotter, Jerome I., Konkle, Barbara A., Johnsen, Jill M., Ashley-Koch, Allison E., Telen, Marilyn J., Sheehan, Vivien A., Blangero, John, Curran, Joanne E., Peralta, Juan M., Montgomery, Courtney, Sheu, Wayne H-H, Chung, Ren-Hua, Schwander, Karen, Nouraie, Seyed M., Gordeuk, Victor R., Zhang, Yingze, Kooperberg, Charles, Reiner, Alexander P., Jackson, Rebecca D., Bleecker, Eugene R., Meyers, Deborah A., Li, Xingnan, Das, Sayantan, Yu, Ketian, LeFaive, Jonathon, Smith, Albert, Blackwell, Tom, Taliun, Daniel, Zollner, Sebastian, Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Pandit, Anita, Zawistowski, Matthew, Kheterpal, Sachin, Brummett, Chad M., Natarajan, Pradeep, Schlessinger, David, Lee, Seunggeun, Kang, Hyun Min, Cucca, Francesco, Holmen, Oddgeir L., Åsvold, Bjørn O., Boehnke, Michael, Kathiresan, Sekar, Abecasis, Goncalo R., Chen, Y. Eugene, Willer, Cristen J., Hveem, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749177/
https://www.ncbi.nlm.nih.gov/pubmed/33339817
http://dx.doi.org/10.1038/s41467-020-20086-3