Cellular proteostasis decline in human senescence

Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remained unclear. Here, we demonstrate that proteostasis decline is intrinsic to human senescence. Using tr...

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Detalles Bibliográficos
Autores principales: Sabath, Niv, Levy-Adam, Flonia, Younis, Amal, Rozales, Kinneret, Meller, Anatoly, Hadar, Shani, Soueid-Baumgarten, Sharon, Shalgi, Reut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749315/
https://www.ncbi.nlm.nih.gov/pubmed/33257563
http://dx.doi.org/10.1073/pnas.2018138117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749315/
https://www.ncbi.nlm.nih.gov/pubmed/33257563
http://dx.doi.org/10.1073/pnas.2018138117

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