Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-stimulated gene screen against vesicular stomatitis virus (VSV)-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH...

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Detalles Bibliográficos
Autores principales: Zang, Ruochen, Case, James Brett, Yutuc, Eylan, Ma, Xiucui, Shen, Sheng, Gomez Castro, Maria Florencia, Liu, Zhuoming, Zeng, Qiru, Zhao, Haiyan, Son, Juhee, Rothlauf, Paul W., Kreutzberger, Alex J. B., Hou, Gaopeng, Zhang, Hu, Bose, Sayantan, Wang, Xin, Vahey, Michael D., Mani, Kartik, Griffiths, William J., Kirchhausen, Tom, Fremont, Daved H., Guo, Haitao, Diwan, Abhinav, Wang, Yuqin, Diamond, Michael S., Whelan, Sean P. J., Ding, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749331/
https://www.ncbi.nlm.nih.gov/pubmed/33239446
http://dx.doi.org/10.1073/pnas.2012197117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749331/
https://www.ncbi.nlm.nih.gov/pubmed/33239446
http://dx.doi.org/10.1073/pnas.2012197117

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