The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease

Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer’s disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore a prime target for therapeutic options. The inactive IL-1β precursor requires processing by the the nucleotide-bindi...

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Detalles Bibliográficos
Autores principales: Lonnemann, Niklas, Hosseini, Shirin, Marchetti, Carlo, Skouras, Damaris B., Stefanoni, Davide, D’Alessandro, Angelo, Dinarello, Charles A., Korte, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749353/
https://www.ncbi.nlm.nih.gov/pubmed/33257576
http://dx.doi.org/10.1073/pnas.2009680117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749353/
https://www.ncbi.nlm.nih.gov/pubmed/33257576
http://dx.doi.org/10.1073/pnas.2009680117

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