Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis

BACKGROUND: Chelocardin (CHD) exhibits a broad-spectrum antibiotic activity and showed promising results in a small phase II clinical study conducted on patients with urinary tract infections. Importantly, CHD was shown to be active also against tetracycline-resistant Gram-negative pathogens, which...

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Detalles Bibliográficos
Autores principales: Lukežič, Tadeja, Pikl, Špela, Zaburannyi, Nestor, Remškar, Maja, Petković, Hrvoje, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749508/
https://www.ncbi.nlm.nih.gov/pubmed/33341113
http://dx.doi.org/10.1186/s12934-020-01495-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749508/
https://www.ncbi.nlm.nih.gov/pubmed/33341113
http://dx.doi.org/10.1186/s12934-020-01495-x

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