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Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis
BACKGROUND: Chelocardin (CHD) exhibits a broad-spectrum antibiotic activity and showed promising results in a small phase II clinical study conducted on patients with urinary tract infections. Importantly, CHD was shown to be active also against tetracycline-resistant Gram-negative pathogens, which...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749508/ https://www.ncbi.nlm.nih.gov/pubmed/33341113 http://dx.doi.org/10.1186/s12934-020-01495-x |