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Brain metabolites in cholinergic and glutamatergic pathways are altered by pancreatic cancer cachexia

BACKGROUND: Cachexia is a major cause of morbidity in pancreatic ductal adenocarcinoma (PDAC) patients. Our purpose was to understand the impact of PDAC‐induced cachexia on brain metabolism in PDAC xenograft studies, to gain new insights into the causes of cachexia‐induced morbidity. Changes in mous...

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Detalles Bibliográficos
Autores principales: Winnard, Paul T., Bharti, Santosh Kumar, Sharma, Raj Kumar, Krishnamachary, Balaji, Mironchik, Yelena, Penet, Marie‐France, Goggins, Michael G., Maitra, Anirban, Kamel, Ihab, Horton, Karen M., Jacobs, Michael A., Bhujwalla, Zaver M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749557/
https://www.ncbi.nlm.nih.gov/pubmed/33006443
http://dx.doi.org/10.1002/jcsm.12621